So the answer is that they do work against each other?It may not be optimal damage, but it is still additional damage that your doing despite being at 50% effeciency during that 30 sec of entangle. Extra damage is extra damage and every little bit helps.
just "thinking out loud" about our various skills and how well they work, or don't work. Def Spike is something I'm looking into for my ranger, but it doesn't sound like it really work that well with Bolas either, for me at least, since bolas = nothing hitting me, nothing getting hit by spikes. I can see benefits of it, say on the tank. Entangle would help too, but like the question asked, it "hurts" Def spikes as well.